Hyperosmolarity has been shown to cause human epithelial damage and cell death

This publication discusses the evidence shown using the TearLab Osmolarity System and HLA-DR antigen results that confirm the role of played by tear osmolarity in initiating and perpetuating the cycle of inflammation in Dry Eye Disease…

http://www.iovs.org/content/early/2011/04/14/iovs.11-7215.abstract

 

Hyperosmolar Stress Upregulates HLA-DR Expression in Human Conjunctival Epithelium in Dry Eye Patients and In VitroModels
by, Piera Versura, Vincenzo Profazio, Costantino Schiavi and Emilio C Campos

 

 

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