Dr. Eldridge began an interesting thread this past week regarding ocular surface disease in glaucoma patients. He reminded us that dry eye disease can often be silent in patients after chronic administration of BAK preservatives have reduced corneal … [Read more...]
Chronic BAK exposure is associated with an increase in tear osmolarity
January 27, 2012 By Leave a Comment
Diurnal variation of tear osmolarity in normal subjects measured by a new microchip system
January 11, 2012 By Leave a Comment
Normal subjects showed no variation over a day, confirming that a properly functioning tear film is characterized by its low and stable concentration. This study provides further evidence that eye-to-eye variability is the hallmark of Dry Eye Disease. As shown in Lemp et al. [AJO 2011], dry eye disease subjects showed … [Read more...]
Clinical Utility of Tear Osmolarity
August 5, 2011 By Leave a Comment
Dry Eye is a disease of the tears and ocular surface that results in fluctuating vision, tear film instability and increased osmolarity which can cause damage to the ocular surface. According to the 2007 Tear Film & Ocular Surface Society Report of the International Dry Eye WorkShop (DEWS): “The core mechanisms of dry eye … [Read more...]
Dry Eye Disease – The Arthritis of the Eye
October 13, 2010 By Leave a Comment
Part of the difficulty in assessing the clinical severity of mild to moderate dry eye disease lies in the myriad of factors that contribute to its progression. During my studies as a biomedical engineer, we were trained to look for the mechanism of the disease, to make salient estimates of the physical and chemical forces that … [Read more...]
An objective approach to dry eye disease severity (from iovs.org)
July 15, 2010 By Leave a Comment
Published by The Association for Research in Vision and Ophthalmology, Inc. http://www.iovs.org/cgi/content/abstract/iovs.10-5390v1?papetoc&eaf Benjamin D Sullivan,1 Diane Whitmer,2 Kelly K Nichols,3 Alan Tomlinson,4 Gary N Foulks,5 Gerd Geerling,6 Jay S Pepose,7 Valerie Kosheleff,8 Allison Porreco,9 and Michael A … [Read more...]
Impact of time between collection on osmolarity of human tear fluid.
May 23, 2010 By Leave a Comment
[Source: Adam Keech, Michelle Senchyna, Benjamin Sullivan, Michael A. Lemp, Lyndon Jones.] Purpose. Previous research has indicated that reflex tearing may be signifcantly hypoosmolar as compared to the equilibrated, basal tear film. However, neither the degree of perturbation nor the length of time required for the osmolarity … [Read more...]
